Creators of an elegant and ideal compounding base

About Derm3Labs

High quality standards

It took some time and research, but the cause was a worthy one. And worthy causes always inspire. We needed to produce a transdermal base for patients with extremely sensitive skin and we did so with Permeabase.

Transdermal Cream Base, a Proprietary Base

Permeabase®

Permeabase® Transdermal Cream Base is an oil-in-water off-white vanishing cream specially formulated with Chemical Penetration Enhancers (CPEs) to assist with the penetration of high percentages of active pharmaceutical ingredients (APIs) for optimal transdermal drug delivery.

Description: Ready-to-use, time-saving compounding vehicle, compatible with a broad range of APIs, to prepare topical medications in cream dosage form.

It retains its consistency with a wide variety of APIs and solvents.
Its hydrophilicity and lipophilicity support both water and lipid soluble drugs.

Qualities:

Smooth and soft, non-greasy, vanishing cream, providing an exquisite skin feel, helping improve patient adherence.
An elegant alternative to traditional PLO bases (Pluronic Lecithin Organogels).
Does not require the use of an occlusive dressing.
Mineral oil, petrochemicals, parabens, and petrolatum free.
Methylisothiazolinone and Methylchloroisothiazolinone (MI/MCI) free: this combination is widely used as a preservative; and has been associated with allergic reactions. Health Canada states that a product containing MI/MCI should be wiped off skin immediately after use, and therefore should not be used in a cream intended to stay on the skin.

Reliability:

Used in Multiprofen CC™ topical pain cream, US Patent US9707197B2 and Canada Patent CA2907250C
Used in Multiprofen CC ABX™ topical antibiotic cream, US Patent US11311550B2 and Canada Patent CA3066134A1
No Objection Letter (NOL 276712) granted by Health Canada for the use in the Clinical Trial “Multiprofen CC™ to Reduce Pain After Total Knee Arthroplasty (NCT06202989)”
4000+ Medical Prescribers confident in the product
Manufactured in a GMP, HACCP & ISO 9001 certified facility
Passed USP 51 Antimicrobial Effectiveness Test